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D significant.Sense - 5' CGAAGCUUAUUUCUGAGGAtt 3' Antisense - 5' UCCUCAGAAAUAAGCUUCGtc 3' A non-silencing mismatch siRNA, Silencer Negative Control #1 (AM4635), was used as a negative control. Transfection of siRNA duplexes was performed with Ambion Silencer siPORT NeoFX reagent (AM4510) according to the manufacturer's instructions. Briefly, siRNA was diluted in serum-free minimum essential medium