Matinib by targeting endothelial cells or other important cell types, such as macrophages, in the tumor microenvironment. However, the present study is limited to an in vitro cell culture system. Mouse model studies are needed to further investigate whether the effects of IGFBP3 extend to the GIST microenvironment.Figure IGFBP3 overexpression on GIST-T1 cell sensitivity to imatinib Effect of5 Effe