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N RBA-1 cells. Next, to determine whether activation of CaMKII by LTA was mediated through Ca2+ signaling, an upstream signaling molecule of CaM/CaMKII cascade, cells wereWang et al. Journal of Neuroinflammation 2010, 7:84 http://www.jneuroinflammation.com/content/7/1/Page 9 ofFigure 4 Involvement CaMKII in LTA-induced MMP-9 expression in RBA-1. (A, B) Cells were pretreated with inhibitors of calm