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W.molecular-cancer.com/content/8/1/induced effects on cell viability and imatinib response in GIST882 or GIST-T1. Additional studies are needed to determine IGF and IGF-1R expression levels and IGF sensitivity in GIST cell lines and to further examine whether IGFBP3 functions through an IGF-dependent or IGF-independent mechanism in GIST. In addition to its direct effects on cancer cells, IGFBP3, a
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